"If an inversion is like flipping a series of highway exits, then a translocation is like swapping half of New Jersey with half of Montana. And like a map with new borders, moving parts of chromosomes generates DNA sequences that are not usually next to each other – which is what genome sequencing picks up that microarrays cannot. Sometimes the new borders won't hurt anyone, but sometimes they'll disrupt something vital – both in the geographical analogy and in the genome."